Mitochondrial FNIP1 Recruitment in the Reductive Stress Response

Redox homeostasis is essential for cell health. It can be perturbed by an overproduction of reactive oxygen species (ROS), which leads to oxidative stress. The converse, reductive stress, is caused by mitochondrial inactivation and depletion of ROS. Persistent reductive stress impairs metazoan development and causes cancer, diabetes, and cardiomyopathy. Despite its central role in development and disease, how reductive stress is sensed and alleviated remains poorly understood. The Rape Lab recently identified the first pathway that can counteract reductive stress. Following reductive stress, the E3 ligase CUL2FEM1B marks the FNIP1 proteins for degradation at the outer mitochondrial membrane, which increases electron transport chain activity and resupplies cells with ROS. I hypothesize that localized FNIP1 degradation allows the reductive stress pathway to accurately sense mitochondrial ROS production. The primary goal of my SURF project is to determine how FNIP1 is recruited to the mitochondria. This is essential to understanding how a […]

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Quantum Material Study of Spintronics

Data loss is a major issue in modern electronics. Charged-based devices are vulnerable to ionizing radiation, while ferromagnetic-based memory devices are susceptible to data loss from external magnetic fields. However, Antiferromagnetic (AFM)-based memory devices are robust to both charge and magnetic field perturbations. There exist a few materials whose AFM spin textures can be electrically switched”: an applied current induces a spin polarization, exerting a spin-orbit torque on the magnetic domains. This torque rotates the conductivity tensor, providing a switch between distinct resistance states. My research seeks to leverage the correlated behavior of transition metal dichalcogenides (TMD) that exhibit superconductivity, magnetism, charge density waves (CDW), and Mott physics. Magnetically intercalated TMDs can possess competing AFM orders, which can form a platform to build electrically switchable antiferromagnetic-based devices. Analogous to the AFM domains, we also seek to explore the possibility of electrically controlling the electronic charge order reconstruction of CDWs found […]

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