Stressor Controllability Effects and Stress-Induced Suppression of Adult Hippocampal Neurogenesis
My research will focus on the effects of stress on neurogenesis (the birth of new neurons) in the dentate gyrus (DG) of the adult rat hippocampus. The hippocampus is essential for memory and learning function. Interestingly, chronic stress has been shown to decrease cell proliferation in the DG and reduce the effectiveness of hippocampuss memory function. My project will investigate one potential factor that may prevent stress-induced reduction of neurogenesis: controllability. Studies have shown that animals that can control the onset/offset of stress do not show many negative effects of uncontrollable stress. I will try to recreate the data, found in previous research, in the presence of controls for the stress effect that other studies did not have.
Message to Sponsor
- Major: Molecular and Cell Biology
- Mentor: Daniela Kaufer, Integrative Biology