Target-Specific Input Architecture of Cingulate Cortex Pyramidal Neurons
Many recent studies have shown that the brains frontal cortex strongly modulates the information processed in the primary sensory cortices. A strong contributor of this modulation, each of the frontal cortical pyramidal neurons can project axons to multiple different brain regions (e.g., thalamus, midbrain, striatum, and other cortical areas) and therefore have fundamentally different roles. However, it is still unknown whether the frontal cortical pyramidal neurons innervating different targets receive inputs from overlapped brain regions or from segregated regions. My research will focus on the cingulate cortex (Cg), the frontal cortex modulating visual response and controlling eye movement in mouse models, and I will use a unique Cre-dependent trans-synaptic tracing method based on pseudotyped rabies virus to examine the input architecture of the Cg pyramidal neurons targeting the primary visual cortex (V1) or the superior colliculus (SC). I am enthusiastic that this study will ultimately result in a more thorough anatomical understanding of the focused regions, opening more opportunities to investigate the importance of these neurons circuitry for regulation of various physiological functions.
Message to Sponsor
- Major: Molecular and Cell Biology
- Sponsor: Rose Hills
- Mentor: Yang Dan, Molecular and Cell Biology