Single-molecule analysis of the AMPA receptor2 TARP interaction
This summer I will be researching the interaction between Transmembrane AMPA-receptor regulatory proteins (TARPS) and AMPA glutamate receptors at the single molecule level. In order to do this I will have to make constructs containing fluorescent proteins paired with various members of the TARP family and AMPA glutamate receptor family. The interaction between TARPs and AMPA receptors particularly interesting because TARPs play a critical role in the regulation of synaptic AMPA receptor trafficing. While TARPs are not the only protein involved in this regulation it is believed that the regulation of these receptors underlies some forms of synaptic plasticity, a molecular correlate of learning and memory.
Message to Sponsor
- Major: Molecular and Cell Biology
- Mentor: Lu Chen, Molecular and Cell Biology