The Affect of 9-cis-Retinoic Acid on Glucose Stimulated Insulin Secretion
9-cis-retinoic acid (9cRA) is one of the many derivatives of vitamin A. Although vitamin A derivatives are most known for their involvement in sight, they are involved in many physiological process such as the immune response, the development of many organs, and the maintenance of normal internal conditions like blood glucose. Normally, glucose levels are closely regulated by hormones of the pancreas such as insulin and glucagons. However in the case of diabetes, this tight regulation collapses. 9cRA has shown potential in correcting the hormonal imbalance characteristic of diabetes. How 9cRA does this is a bit of a mystery. This summer, I aim to shed some light on this interesting mystery which may yield valuable information for the development of drug treatments for diabetes.
Message to Sponsor
- Mentor: Joseph Napoli, Nutritional Science and Technology