Effect of endometrial decidualization on Chlamydia trachomatis infection
Women who are on birth control pills are at higher risk for Chlamydia trachomatis (Ct) infection than women not on birth control pills. There is also evidence that women whose endometrium is decidualized during the secretory phase of the menstrual cycle are more susceptible to Ct infection compared to women in other phases of their cycle. However, the basis for this susceptibility to Ct infection is poorly understood at a molecular level. We have previously shown that an increase in the availability of the fatty acid oleic acid (OA) to the Ct infected cell prolongs the time it takes for Ct to differentiate from metabolically active reticulate bodies (RBs) to metabolically inert but infectious elementary bodies (EBs), leading to a greater number of infectious progeny at the end of the organisms developmental cycle. Therefore, I want to examine the role of lipid metabolism changes that occur naturally during decidualization of the endometrium on the intracellular development and infectivity of Ct. I hypothesize that the susceptibility demonstrated in OA treatment of primary endometrial cells is linked to the susceptibility demonstrated in decidualization.
Message to Sponsor
- Major: MCB and IB
- Sponsor: Thye L&S
- Mentor: Deborah Dean